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		<id>https://wiki-planet.win/index.php?title=What_Does_%E2%80%98Other_Treatments_Have_Not_Worked%E2%80%99_Mean_for_MS_Spasticity_THC_CBD_Spray%3F&amp;diff=2386418</id>
		<title>What Does ‘Other Treatments Have Not Worked’ Mean for MS Spasticity THC CBD Spray?</title>
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		<updated>2026-09-06T12:37:22Z</updated>

		<summary type="html">&lt;p&gt;Alanking3: Created page with &amp;quot;&amp;lt;html&amp;gt;&amp;lt;p&amp;gt; If you or someone you care about has multiple sclerosis (MS) and struggles with spasticity—a stiffness or involuntary muscle tightness—you may have heard about the MS spasticity THC CBD spray. It’s one of the few cannabis-based medicines that&amp;#039;s caught attention for symptom relief. However, if you&amp;#039;ve researched NHS prescribing rules or spoken to clinics, you might be puzzled by the constant phrase: &amp;lt;strong&amp;gt; “other treatments have not worked.”&amp;lt;/strong&amp;gt;...&amp;quot;&lt;/p&gt;
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&lt;div&gt;&amp;lt;html&amp;gt;&amp;lt;p&amp;gt; If you or someone you care about has multiple sclerosis (MS) and struggles with spasticity—a stiffness or involuntary muscle tightness—you may have heard about the MS spasticity THC CBD spray. It’s one of the few cannabis-based medicines that&#039;s caught attention for symptom relief. However, if you&#039;ve researched NHS prescribing rules or spoken to clinics, you might be puzzled by the constant phrase: &amp;lt;strong&amp;gt; “other treatments have not worked.”&amp;lt;/strong&amp;gt; What does this actually mean? Why is this phrase so critical to prescribing, especially under NHS rules? And how did the 2018 rescheduling of cannabis-based products change the landscape?&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; In this post, I’ll break down key issues related to the NHS prescribing criteria for this treatment, the impact of the 2018 rescheduling, the importance of specialist-only prescribing, the distinction between legal prescribing and NHS funding, and what unlicensed cannabis-based medicines mean for NHS caution.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; Along the way, I’ll reference medicalcannabis.co.uk—a useful clinic directory and comparison site—and releaf.co.uk—an excellent explainer resource to learn more about MS spasticity treatments.&amp;lt;/p&amp;gt; &amp;lt;h2&amp;gt; Background: What Is MS Spasticity THC CBD Spray?&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; The &amp;lt;strong&amp;gt; ms spasticity thc cbd spray&amp;lt;/strong&amp;gt; is a cannabis-based oromucosal spray containing both tetrahydrocannabinol (THC) and cannabidiol (CBD). Licensed as Sativex®, it is specifically approved in the UK to treat moderate to severe spasticity in MS patients who have not responded well to other medications.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; Because THC is psychoactive while CBD is not, this combination aims to balance symptom relief with tolerability. The spray is administered under the tongue several times a day.&amp;lt;/p&amp;gt; &amp;lt;h2&amp;gt; 2018 Rescheduling: What Changed and Why Does It Matter?&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; Before late 2018, cannabis-derived medicines including THC/CBD sprays were classified as Schedule 1 substances under UK law, which meant they were considered to have no medicinal value and could not be prescribed legally by doctors.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; The &amp;lt;strong&amp;gt; rescheduling&amp;lt;/strong&amp;gt; on November 1, 2018, reclassified cannabis-based products for medicinal use as Schedule 2 controlled drugs. &amp;lt;a href=&amp;quot;https://vergemagazine.co.uk/can-you-get-medical-cannabis-on-the-nhs-a-guide-to-the-uk-system/&amp;quot;&amp;gt;https://vergemagazine.co.uk/can-you-get-medical-cannabis-on-the-nhs-a-guide-to-the-uk-system/&amp;lt;/a&amp;gt; This important regulatory change meant doctors could legally prescribe licensed cannabis-based medicines, including the MS spasticity THC CBD spray, subject to usual prescribing controls.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; &amp;lt;strong&amp;gt; Key takeaway:&amp;lt;/strong&amp;gt; Before 2018, legal prescribing was virtually impossible on the NHS. After rescheduling, specialist doctors could legally prescribe, although NHS funding remains limited and tightly restricted.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt; &amp;lt;img  src=&amp;quot;https://images.pexels.com/photos/39238635/pexels-photo-39238635.jpeg?auto=compress&amp;amp;cs=tinysrgb&amp;amp;h=650&amp;amp;w=940&amp;quot; style=&amp;quot;max-width:500px;height:auto;&amp;quot; &amp;gt;&amp;lt;/img&amp;gt;&amp;lt;/p&amp;gt; &amp;lt;h2&amp;gt; ‘Other Treatments Have Not Worked’: Decoding NHS Prescribing Criteria&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; One of the persistent hurdles for people seeking MS spasticity THC CBD sprays on the NHS is meeting the phrase &amp;lt;strong&amp;gt; “other treatments have not worked”.&amp;lt;/strong&amp;gt; This is part of NICE (National Institute for Health and Care Excellence) and NHS England criteria that must typically be satisfied before the spray can be prescribed and funded on the NHS.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; &amp;lt;strong&amp;gt; In plain terms:&amp;lt;/strong&amp;gt; NHS doctors generally need to see that you have already tried–and not adequately improved with–standard, licensed anti-spasticity medications such as baclofen, tizanidine, or dantrolene. Only if these first-line treatments don’t provide sufficient relief or cause intolerable side effects will the THC CBD spray be considered.&amp;lt;/p&amp;gt; &amp;lt;h3&amp;gt; Why This Matters in Practice&amp;lt;/h3&amp;gt; &amp;lt;ul&amp;gt;  &amp;lt;li&amp;gt; It’s not enough to simply want the spray; documentation from your neurologist or MS specialist showing prior treatment attempts is essential.&amp;lt;/li&amp;gt; &amp;lt;li&amp;gt; The “four-week THC CBD spray trial” mentioned in guidelines refers to an initial test period to assess how well you respond and tolerate the spray.&amp;lt;/li&amp;gt; &amp;lt;li&amp;gt; If after the trial there’s no clear benefit, the treatment should be stopped; if beneficial, NHS funding might continue depending on local policies.&amp;lt;/li&amp;gt; &amp;lt;/ul&amp;gt; &amp;lt;p&amp;gt; This commissioning control helps ensure NHS resources are used effectively and that the treatment is reserved for patients most likely to benefit.&amp;lt;/p&amp;gt; &amp;lt;h2&amp;gt; Specialist-Only Prescribing Rules: What Does That Mean?&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; The MS spasticity THC CBD spray falls under &amp;lt;strong&amp;gt; specialist-only prescribing&amp;lt;/strong&amp;gt;. This means that only certain qualified specialists—typically NHS neurologists, rehabilitation physicians, or MS consultants—can prescribe it confidently.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; General practitioners (GPs) cannot initiate treatment with this medication. Even after a trial, ongoing prescribing responsibility might eventually transfer to the GP but only with specialist guidance and approval.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; &amp;lt;strong&amp;gt; Why specialist-only prescribing?&amp;lt;/strong&amp;gt;&amp;lt;/p&amp;gt; &amp;lt;ul&amp;gt;  &amp;lt;li&amp;gt; The medication requires careful dose titration and monitoring.&amp;lt;/li&amp;gt; &amp;lt;li&amp;gt; Side effects and interactions need specialist assessment.&amp;lt;/li&amp;gt; &amp;lt;li&amp;gt; Prescribing needs to meet strict NHS criteria and documentation.&amp;lt;/li&amp;gt; &amp;lt;/ul&amp;gt; &amp;lt;h2&amp;gt; NHS Funding vs Legal Prescribing: Understanding the Difference&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; This is often misunderstood. After the 2018 rescheduling, cannabis-based medicines became legal to prescribe. However, &amp;lt;strong&amp;gt; legal prescribing does not automatically mean NHS funding.&amp;lt;/strong&amp;gt;&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; Doctors can technically legally prescribe the spray privately if they feel it’s appropriate. But securing NHS funding—a criteria-based approval from Clinical Commissioning Groups (CCGs) or NHS England—is a separate, often more complex process.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; This explains the popularity of sites like medicalcannabis.co.uk, which help patients find private clinics offering assessments and access to cannabis-based medicines where NHS funding is unavailable.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt; &amp;lt;img  src=&amp;quot;https://images.pexels.com/photos/6010870/pexels-photo-6010870.jpeg?auto=compress&amp;amp;cs=tinysrgb&amp;amp;h=650&amp;amp;w=940&amp;quot; style=&amp;quot;max-width:500px;height:auto;&amp;quot; &amp;gt;&amp;lt;/img&amp;gt;&amp;lt;/p&amp;gt; &amp;lt;h2&amp;gt; Unlicensed Cannabis-Based Medicines and NHS Caution&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; The MS spasticity THC CBD spray is a licensed medicine, but many other cannabis-based products in the UK are unlicensed. Unlicensed medicines have not undergone the full regulatory approval process.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; The NHS is very cautious about endorsing or funding unlicensed cannabis products because:&amp;lt;/p&amp;gt; &amp;lt;ul&amp;gt;  &amp;lt;li&amp;gt; Their safety, efficacy, and quality cannot be guaranteed.&amp;lt;/li&amp;gt; &amp;lt;li&amp;gt; They carry legal and reimbursement complexities.&amp;lt;/li&amp;gt; &amp;lt;li&amp;gt; They lack robust clinical trial evidence aligned with NICE standards.&amp;lt;/li&amp;gt; &amp;lt;/ul&amp;gt; &amp;lt;p&amp;gt; Specialist prescribers who do recommend or prescribe unlicensed cannabis-based products need to carefully document clinical reasons and monitor outcomes.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt; &amp;lt;iframe  src=&amp;quot;https://www.youtube.com/embed/pDlJO9o0yIk&amp;quot; width=&amp;quot;560&amp;quot; height=&amp;quot;315&amp;quot; style=&amp;quot;border: none;&amp;quot; allowfullscreen=&amp;quot;&amp;quot; &amp;gt;&amp;lt;/iframe&amp;gt;&amp;lt;/p&amp;gt; &amp;lt;h2&amp;gt; Summary Table: Key Differences and Facts About MS Spasticity THC CBD Spray&amp;lt;/h2&amp;gt;     Aspect Details     Product Licensed cannabis-based oromucosal spray with balanced THC and CBD (e.g., Sativex®)   Legal Status Rescheduled to Schedule 2 in 2018, legal to prescribe by specialists   NHS Funding Restricted; requires documented failure of other treatments and a positive initial trial   Prescribing Specialist-only initiation; ongoing management with specialist oversight   Trial Period Typically a 4-week trial to assess benefits and side effects   Unlicensed Cannabis Products No NHS funding; used cautiously by specialists if at all   Private Access Available via private clinics like those listed on medicalcannabis.co.uk    &amp;lt;h2&amp;gt; What About Costs? A Note on Prices&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; No specific public prices were stated in the sources I reviewed. Prices vary widely depending on whether treatment is NHS-funded, privately prescribed, or supplied by pharmacies via NHS contracts.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; If in future or external sources you find exact UK prices for the MS spasticity THC CBD spray, it’s important to quote the price exactly and attribute the source appropriately. Until then, relying on reputable clinic comparison websites or direct NHS contact is best to get relevant up-to-date cost info.&amp;lt;/p&amp;gt; &amp;lt;h2&amp;gt; Further Resources&amp;lt;/h2&amp;gt; &amp;lt;ul&amp;gt;  &amp;lt;li&amp;gt; Medical Cannabis UK Clinic Directory: Compare private clinics, check specialist prescribers, and read patient reviews.&amp;lt;/li&amp;gt; &amp;lt;li&amp;gt; ReLeaf.co.uk Explainer: Easy-to-understand guides on what cannabis-based medicines are and how NHS access works.&amp;lt;/li&amp;gt; &amp;lt;/ul&amp;gt; &amp;lt;h2&amp;gt; Final Thoughts&amp;lt;/h2&amp;gt; &amp;lt;p&amp;gt; “Other treatments have not worked” might feel like a barrier, but it’s really about ensuring the MS spasticity THC CBD spray is used responsibly and effectively for those who have exhausted standard options. Thanks to the 2018 rescheduling, legal access has improved dramatically—but NHS funding and specialist prescribing rules keep use cautious and controlled.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; If you are considering this treatment, it pays to talk openly with your MS specialist, understand the NHS criteria, and explore trusted resources. Remember: legal prescribing ≠ automatic NHS funding, and specialist involvement is essential.&amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; Ultimately, for many MS patients battling disabling spasticity, this treatment can represent an important option—but one that comes with clinical guardrails to maximise benefits and minimise risks.&amp;lt;/p&amp;gt;&amp;lt;/html&amp;gt;&lt;/div&gt;</summary>
		<author><name>Alanking3</name></author>
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